| Ngày | Giờ | Trận đấu | Sân | ||
|---|---|---|---|---|---|
| 14-08-2021 | 21:00 |
Everton 
|
3 - 1 |
Southampton
|
Goodison Park |
| 22-08-2021 | 20:00 |
Southampton
|
1 - 1 |
 Man Utd
|
Saint Mary's |
| 28-08-2021 | 21:00 |
Newcastle 
|
2 - 2 |
Southampton
|
St. James' Park |
| 11-09-2021 | 21:00 |
Southampton
|
0 - 0 |
 West Ham
|
St. mary's |
| 18-09-2021 | 21:00 |
Man City 
|
0 - 0 |
Southampton
|
Etihad |
| 26-09-2021 | 20:00 |
Southampton
|
0 - 1 |
 Wolveshampton
|
St, Mery's |
| 02-10-2021 | 21:00 |
Chelsea 
|
3 - 1 |
Southampton
|
Stamford Bridge |
| 16-10-2021 | 21:00 |
Southampton
|
1 - 0 |
 Leeds Utd
|
St. Mary's |
| 23-10-2021 | 21:00 |
Southampton
|
2 - 2 |
 Burnley
|
St. Mary's |
| 30-10-2021 | 21:00 |
Watford 
|
0 - 1 |
Southampton
|
Vicarage |
| 06-11-2021 | 03:00 |
Southampton
|
1 - 0 |
 Aston Villa
|
St. Mary's |
| 20-11-2021 | 22:00 |
Norwich City 
|
2 - 1 |
Southampton
|
Carrow Road |
| 27-11-2021 | 22:00 |
Liverpool 
|
4 - 0 |
Southampton
|
Anfield |
| 02-12-2021 | 02:30 |
Southampton
|
2 - 2 |
 Leicester City
|
St. Mary's |
| 04-12-2021 | 22:00 |
Southampton
|
1 - 1 |
 Brighton
|
St. Mary's |
| 11-12-2021 | 22:00 |
Arsenal 
|
3 - 0 |
Southampton
|
Emirates |
| 16-12-2021 | 02:30 |
Crystal Palace 
|
2 - 2 |
Southampton
|
Selhurst Park |
| 26-12-2021 | 22:00 |
West Ham
|
2 - 3 |
Southampton
|
London |
| 28-12-2021 | 22:00 |
Southampton
|
1 - 1 |
 Tottenham Hotspur
|
St. Mary's |
| 12-01-2022 | 02:45 |
Southampton
|
4 - 1 |
 Brentford
|
St. Mary's |
| 15-01-2022 | 22:00 |
Wolveshampton
|
3 - 1 |
Southampton
|
Molineux |
| 23-01-2022 | 00:30 |
Southampton
|
1 - 1 |
Man City
|
St. Mary's |
| 10-02-2022 | 02:45 |
Tottenham Hotspur
|
2 - 3 |
Southampton
|
Tottenham Hotspur |
| 12-02-2022 | 19:30 |
Man Utd
|
1 - 1 |
Southampton
|
Old Trafford |
| 19-02-2022 | 22:00 |
Southampton
|
2 - 0 |
Everton
|
St. Mary's |
| 26-02-2022 | 03:00 |
Southampton
|
2 - 0 |
Norwich City
|
St. Mary's |
| 05-03-2022 | 22:00 |
Aston Villa
|
4 - 0 |
Southampton
|
Villa Park |
| 11-03-2022 | 02:30 |
Southampton
|
1 - 2 |
Newcastle
|
St. Mary's |
| 13-03-2022 | 21:00 |
Southampton
|
1 - 2 |
Watford
|
St. Mary's |
| 02-04-2022 | 21:00 |
Leeds Utd
|
1 - 1 |
Southampton
|
Elland Road |
| 09-04-2022 | 21:00 |
Southampton
|
0 - 6 |
Chelsea
|
St. Mary's |
| 16-04-2022 | 21:00 |
Southampton
|
1 - 0 |
Arsenal
|
St. Mary's |
| 22-04-2022 | 01:45 |
Burnley
|
2 - 0 |
Southampton
|
Turf Moor |
| 24-04-2022 | 20:00 |
Brighton
|
2 - 2 |
Southampton
|
Amex |
| 30-04-2022 | 21:00 |
Southampton
|
1 - 2 |
Crystal Palace
|
St. Mary's |
| 07-05-2022 | 21:00 |
Brentford
|
3 - 0 |
Southampton
|
Brentford Community |
| 18-05-2022 | 01:45 |
Southampton
|
-vs- |
Liverpool
|
St. Mary's |
| 22-05-2022 | 22:00 |
Leicester City
|
-vs- |
Southampton
|
King Power |
